Best NFL 2025-26 Week 3 Sports Betting Odds - Compare Live Lines & Odds | Tallysight

Odds

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Gamelines

NFL • Arizona Cardinals @ San Francisco 49ersNFL • ARI @ SF

FINAL•9/21 • 8:25PM9/21/25

ARI CardinalsARI

15

@

SF 49ersSF

16

MoneylineMoneyline

SpreadSpread

+1.5+1.5-110-110

-1.5-1.5-110-110

TotalTotal

O 44.5O 44.5-110-110

U 44.5U 44.5-110-110

DJM

279 picks

61%correctly predicted

SFto win

Odds updated7 days ago

Community & Expert Insights

279 picks from 53 verified sources

Moneyline

61%

SF

Spread

56%

SF

Total

69%

Under

Props

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Passing TouchdownsPassing Touchdowns

Kyler MurrayKyler Murray

Mac JonesMac Jones

OverOver

O 1.5O 1.5+140+140

O 1.5O 1.5+130+130

UnderUnder

U 1.5U 1.5-160-160

U 1.5U 1.5-150-150

Player TouchdownsPlayer Touchdowns

Christian McCaffreyChristian McCaffrey

James ConnerJames Conner

Marvin Harrison Jr.Marvin Harrison Jr.

Trey McBrideTrey McBride

OverOver

O 0.5O 0.5-170-170

O 0.5O 0.5+110+110

O 0.5O 0.5+185+185

O 0.5O 0.5+205+205

UnderUnder

U 0.5U 0.5+150+150

U 0.5U 0.5-130-130

U 0.5U 0.5-215-215

U 0.5U 0.5-240-240

Receiving YardsReceiving Yards

Marvin Harrison Jr.Marvin Harrison Jr.

Trey McBrideTrey McBride

OverOver

O 50.5O 50.5-110-110

O 63.5O 63.5-110-110

UnderUnder

U 50.5U 50.5-110-110

U 63.5U 63.5-110-110

Rushing YardsRushing Yards

Christian McCaffreyChristian McCaffrey

James ConnerJames Conner

OverOver

O 69.5O 69.5-110-110

O 50.5O 50.5-110-110

UnderUnder

U 69.5U 69.5-110-110

U 50.5U 50.5-110-110

Anytime Touchdown ScorerAnytime Touchdown Scorer

Christian McCaffreyChristian McCaffrey

James ConnerJames Conner

Marvin Harrison Jr.Marvin Harrison Jr.

Trey McBrideTrey McBride

First Half MoneylineFirst Half Moneyline

San Francisco 49ersSan Francisco 49ers

Arizona CardinalsArizona Cardinals